Control mechanism of force-induced cell-to-cell adhesion

(National Institutes of Natural Sciences) Dr. Naoto Ueno from NIBB, Japan and Dr. Ileana Cristea from Princeton Univ. have demonstrated that physical forces, enhance cell-to-cell attachment and increase the stiffness of embryonic tissues as a result of force induced cell shape change. They have also elucidated a part of the signaling pathway underlying the phenomenon. This work revealing how physical forces build-up the structurally robust and stable embryonic tissue architectures during develop...